Padilla began posting flash animations on Newgrounds in 2003, under the name Smosh. Soon afterward, they began to post videos on You Tube in the autumn of 2005 and became one of the most popular channels on that site.As of September 2016 The Smosh team has expanded to include others to handle animated, other language, and video gaming content videos, and the sketches have included more actors.The Smosh channel has experienced three different spans as the most subscribed You Tube channel.
They became friends, and quickly discovered their knack for comedy.
In 2005, they joined You Tube and made several videos together, lip syncing the theme songs to Mortal Kombat, Power Rangers, and Teenage Mutant Ninja Turtles.
At first, these videos were not intended to be posted online, but after they sent them to their friends, they started a You Tube channel.
One of Smosh's earliest videos, "Pokémon Theme Music Video," was released on November 28, 2005.
It followed the same style as their other earlier videos, featuring the duo lip-synching the original English theme song for the Pokémon anime.
However, the video instantly became much more popular than any of their other videos; over the course of its lifetime, it gained over 24 million views, becoming the most-viewed video on all of You Tube at that time.
Due to the channel's continued success, and Smosh's partnership with You Tube, the two recreated the video in November 2010, this time changing the words to be critical of The Pokémon Company taking down the Pokémon theme video.
In 2009, Smosh prepared a massive redesign of Smosh.com, added a games section, and put extras in the video section.
In January 2010, Smosh launched the "Smosh Pit" feature, a blog that consists of various pieces of pop-culture trivia, and written comedy.
In addition, 2010 saw the channel launch 3 different Smosh-based web series: Ian Is Bored, which started as a collection of comedic videos by Hecox, but then turned into both Hecox and Padilla making vlog like videos, and renamed Smosh Is Bored; Ask Charlie, where people ask Charlie, from their January 2010 Charlie the Drunk Guinea Pig video, random questions; and Lunchtime with Smosh, a comedy series featuring Smosh getting and eating food from various places, and answering Twitter questions from their fans on Twitter.
Some of Smosh's most popular video series include Pokémon in Real Life and If ____ Was Real.